Clear Skin Starts in the Gut — This New Clinical Trial Proves It

Still breaking out no matter how many probiotics or skincare products you’ve tried? If your acne is driven by hormones — especially PCOS-related — a groundbreaking clinical trial study from 2025 from might hold the answer.

🧪 In a clinical trial of women with PCOS (a major trigger of adult hormonal acne), researchers compared two options:

• A probiotic + prebiotic synbiotic formula

• A myoinositol-based polyherbal blend featuring anti-inflammatory and gut-cleansing herbs

⚡ The herbal formula didn’t just win — it outperformed across nearly every parameter that fuels breakouts from within.

📊 Study Results That Matter for Skin:

1. ✅ Cycle Regularity (a marker of hormone stability):

   • 58.1% improved with the herbal blend

   • 35.5% with probiotics

2. 🧬 AMH Levels (key fertility and androgen balance marker):

   • ↑ 24.6% with herbs

   • ↑ 13.2% with probiotics

3. 📉 BMI Decrease (inflammation and insulin sensitivity):

   • ↓ 2.6% with herbs

   • ↓ 1.2% with probiotics

4. 🔄 FSH/LH Hormone Balance (linked to oil production + breakouts):

   • Strongly improved in herbal group

   • Mild/no change in others

🌿 What’s in the Formula?

The herbal supplement combined:

• Myo-inositol & D-chiro-inositol (hormone and insulin regulation)

• Vitamin D & folic acid (skin barrier + cell turnover support)

• Polyherbal extracts including cascara sagrada and goldenseal for colon health, inflammation, and detoxification

👉 No side effects were reported. Just clear, skin-supportive results.

💡 Why This Matters for Hormonal Acne

Because your gut, hormones, and skin are always in sync — if one is off, your face may be the first to tell you. Hormonal acne is less about clogged pores and more about internal imbalance, inflammation, and sluggish detox.

That’s why we love polyherbal colon and metabolic blends like Colon Tonic by Dr. Marco Sikaffy — an iconic formulation that supports:

• 🔄 Natural elimination to keep waste and excess hormones moving

  • 🔥 Reduced inflammatory load in the gut-skin axis

• 🧠 Restored gut-brain-hormone balance

• ✨ Internal reset that shows on your face

Your glow starts in the gut. And the science? It’s catching up fast.